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Reduce, Restore and Regenerate are the 3 R's of Stem Cell Therapy

Reduce Biochemical Imbalances; Restore Cell to Cell Communication and Regenerate New Tissue  by: Edward G. Loniewski, DO, FACOS, FAOAO

Upload: February 3, 2017

A very common question asked by many patients and even well informed and educated doctors is how cell based therapies such as bone marrow derived stem cells may work.   After years of researching and understanding this technology, we can reduce this answer to three simple steps.   Although we could give you more than a hundred mechanisms,  we chose three  since most people can remember 3 steps.  If we have more than three, everyone in our multitasking and attention deficit infused society begins to forget numbers one and two.   Many philosophers such as Camus, Kierkegaard or even Aristotle suggest we narrow down our explanations of complex thought and systems down to three reasons, examples or theories.   Following in this tradition, we  can help simplify this very complex field of healthcare down to three major mechanisms of action for cell based therapies.   These are;

  • Reduce
  • Restore
  • Regenerate


  • Reduce-  Cell based therapies help restore the natural biochemical balance.  We normally have a complex set of biochemical byproducts of cellular maintenance in our joints. When this is in normal balance, it is called homeostasis.  However, as we age, or when trauma or disease occurs in a joint, this balance is interrupted and mass destruction and pain occur. One of the most important biochemical markers is Interleukin 1-Beta ( IL-1 B) .    Although this Interleukin is normally used to clean up cellular debris, arthritic joints produce too much, causing the destruction of the repair.   Each time our body tries to repair itself, this abnormally high amount of Interleukin 1- Beta disrupts this process.   At Advanced Orthopedic Specialists, we can produce a bone marrow derived product from your own cells to naturally reduce the abnormally high levels of the IL-B.  We can filter and concentrate of a natural blocker found in everyone's own bone marrow called Interleukin 1- Beta Receptor Antagonist ( IL-1B Ra) .  Your own body produces this within your bone marrow and in smaller amounts in your blood. We have found a way to concentrate this through a patented filtering process producing over 4 times the concentration found in any other preparation.   Without this important step, it is very difficult for your joint to restore its natural biochemical balance or homeostasis.
  • Restore -   Your joint is an organ just like your brain, kidney, liver or heart.   An organ is made up of cells which perform a specific function necessary for life. These cells carry on their purpose by communicating efficiently between each other.  This is called cell-to-cell communication or a paracrine signaling.   When an organ such as your knee has arthritis, the cells begin to act abnormal and the communication between these cells breaks down. The result is a dysfunctional joint.   This is what happens in a dysfunctional family. Nobody communicates effectively with each other and the family unit begins to break down.     However, Mesenchymal Stem Cells (MSC's) can restore normal paracrine signaling of cells through the release of specific factors designed to restore function of the joint. Thus, when stem cells restore this normal communication, the normal functions of the joint return.  A patented processing technology coupled with a significantly improved cell harvest technique  can improve cell harvesting by over 345%  and return of more than 90% of your cells back to your body.  This provides  the absolute highest number of mesenchymal stem cells to your joint to ensure that your normal cell to cell communication is restored.
  • Regenerate-  Only after a joint has completed the first two steps of this process, can we move forward with the building of new tissue or regeneration.  After we have reduced the levels of harmful biochemical byproducts in your joints to a reasonable or near normal level, and after restoring cell to cell communication, your joint may now begin the process of producing new tissue.   Think about this scenario like a family with an alcoholic father.  There is nothing like alcoholism as a source of family dysfunction.  In fact. there are just about the same number of children with alcoholic parents as there are people with arthritis (about 28 million) in the United States.   If this family is to survive, the first step is to reduce the chemical causing the destruction.  In the family, this is alcohol.   In the joint, this is Interleukin-1- Beta.    The second step is to encourage the family to communicate and re-establish the lines of normal communication.   In the family suffering from alcoholism, this is called therapy and in the joint this is called a paracrine event.   Once the chemical in the family is reduced and the communication is restoredregeneration will be able to occur and the family will be able to function as a normal family and the children will be able to thrive.  In the joint, we have reduced the harmful biochemical imbalance and restored cell to cell communication and new tissue can now regenerate. However, the actual amount of tissue needed for pain relief may be very minimal.   There is no relationship between the amount or volume of new tissue formation and the level of pain relief or the restoration of joint function.  Some people can produce very large amounts of new tissue and have very little change in their pain or function.  However, many patients may have very little, if any, tissue regeneration and have significant pain relief and restoration of function.    Why would this be true?   Think about the last time you had joint pain and you took a simple over the counter medication to relieve this pain.   Most people would have a reduction of their pain.  However, this pain reliever did not grow any new tissue by any means.  These medications are not injected into your joint, and your stomach does not directly connect to your joint.  However, whenever you take a pill, your joint has a good chance that it will feel better and allow you to function at a higher level.   Why is this true? The answer is the fact that these medications help to temporarily reduce some other minor players in the biochemical imbalance of your joint.   Thus, new tissue is not necessary to reduce the pain and restores some of the function to your joint.     Mesenchymal stem cells do this, but through a much more complex system and for a substantially longer period with a positive side effect of possibly growing more tissue.

The use of cell therapy can help your body naturally reduce a harmful chemical imbalance; restore cell to cell communication; and regenerate new tissue all adding up to a joint with lower pain and higher function without side effects or the inconvenience and risk of major surgery.

Concentrating Stem Cell Therapy Naturally

Concentrating Stem Cell Therapy Naturally

By : Edward G. Loniewski, DO, FACOS, FAOAOUpload: March 1, 2017

At Advanced Orthopedic Specialists we strive to provide you with cutting edge technology sometimes not even available at such stalwarts of medical innovation such as John Hopkins; The Mayo Clinic or even the University of Michigan.   One of these advanced technologies involves the concept of concentrating the healing cells from your bone marrow or blood in the joint or area of damage.     The simple filtering of your bone marrow or blood plasma to remove water and salts helps to naturally concentrate the important plasma proteins and growth factors found in this vital fluid found within each and every human.   In the past, stem cell therapy involved spinning your bone marrow or blood at very high speeds to separate it into two to three different layers, namely the red blood cell layer, the platelet poor plasma (PPP) layer; and a platelet/ stem cell  rich plasma ( PRP) layer.  Upload: March 1, 2017

In the past, many researchers or physicians would discard both the red blood cell layer and the platelet poor plasma (PPP) layer.  However, this never really made sense to me since this PPP layer contains many of the growth factors and plasma proteins necessary for continued growth of these cells.  In fact, one of the best growth mediums for mesenchymal stem cells is a special mixture called platelet lysate made from the layer we would normally throw away in the biohazard bag.  The problem using this PPP layer in the past is that it would dilute the mesenchymal stem cells as well as the concentrated platelets we need to activate in your body by forming a clump or a clot.    However, some very smart and practical scientists at Celling Biosciences (Austin, Tx.) used good old fashioned American ingenuity to figure out a simple filtering process which can easily remove water and salts from this PPP to produce a super clot forming; growth factor and plasma protein rich environment for harvested stem cells.  The concept is extremely simple and safe using no drugs or chemicals.  This filtering process is a patented technology only available through a US born and bred company in Austin, Texas.  Celling Bioscience's PhD's have used this self contained filter to significantly enhance the retention and growth of stem cells within your joints.    In fact, they have demonstrated that this technology can increase the concentration of very vital growth factors such as Alpha 2 Macroglobulin (A2M) by a factor of 5.22 , Platelet Derived Growth Factor (PDGF-bb) by a factor of 5.88 , Vascular Endothelial Growth Factor (VEGF) by a factor of 2.27 as well as the very important Interleukin 1 Receptor Antagonist Protein (IRAP) by over 3.77 times the normal amount.   In addition, this concentrating process helps the cells clump in a manner to protect them from migration to other parts of your body and slowly release themselves over a prolonged period of time.   If there is no clumping of these cells within the area of delivery such as within your joint, you may rapidly lose these important cells within minutes.

Upload: March 1, 2017

Mesenchymal stem cells  have a high affinity to blood vessels and travel to your spleen, lymph or circulatory system and away from the area of damage.  Sometimes, stem cell clinics or researchers use artificial clotting agents such as human recombinant (meaning made from DNA taken from another human)  or bovine (meaning from horses) thrombin to create this clot.  The problem is that a percentage of patients react to this drug, and repetitive use of this drug can have an autoimmune response causing pain and swelling and possible cell death.  On the other hand, you should never develop a reaction to a concentrate of your own cells.  In a recent, trial conducted at Celling Biosciences, Matthew Murphy, PhD. was able to demonstrate that the super healthy clot formed from the concentrated plasma proteins allowed the clot to continue to hold it's shape for an amazing 14 days with very high cell counts.   On the other hand, the clot formed by the drug thrombin had started to deteriorate only after 6 days with a much lower cell count.   Dr. Loniewski, has worked with Celling Biosciences to help develop state of the art protocols using this technology  and the most advanced stem cell therapies.  No other center in the United States offers this advanced technology on all of their patients.    This is why we can claim that at least 85% of our patients improve with little to no side effects.   Not all patients respond to these treatments, and not every patient is a candidate for cell based therapies.  If you are interested in cell based treatments, call our office at 810-299-8550 or you can download our on-line stem cell questionnaire to understand if you may be a candidate for this therapy.

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